How many nodes can be managed in a single k8s cluster?

I want to know the largest number of nodes that can be managed in a single k8s cluster. If I want to mange 10000 nodes, can I set up only one k8s cluster?

The limiting factor is really etcd. The largest cluster that I know of using etcd is 20,000 nodes. GKE supports clusters up to 65,000 nodes using Spanner as their backend instead of etcd.

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